KMID : 0545120220320060709
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Journal of Microbiology and Biotechnology 2022 Volume.32 No. 6 p.709 ~ p.717
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Pneumococcal ¥Äpep27 Immunization Attenuates TLRs and NLRP3 Expression and Relieves Murine Ovalbumin-Induced Allergic Rhinitis
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Yu Jae-Ik
Kim Ji-Hoon Nam Ki-El Lee Won-Sik Rhee Dong-Kwon
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Abstract
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Allergic rhinitis (AR), one of the most common inflammatory diseases, is caused by immunoglobulin E (IgE)?mediated reactions against inhaled allergens. AR involves mucosal inflammation driven by type 2 helper T (Th2) cells. Previously, it was shown that the Streptococcus pneumoniae pep27 mutant (¥Äpep27) could prevent and treat allergic asthma by reducing Th2 responses. However, the underlying mechanism of ¥Äpep27 immunization in AR remains undetermined. Here, we investigated the role of ¥Äpep27 immunization in the development and progression of AR and elucidated potential mechanisms. In an ovalbumin (OVA)-induced AR mice model, ¥Äpep27 alleviated allergic symptoms (frequency of sneezing and rubbing) and reduced TLR2 and TLR4 expression, Th2 cytokines, and eosinophil infiltration in the nasal mucosa. Mechanistically, ¥Äpep27 reduced the activation of the NLRP3 inflammasome in the nasal mucosa by down-regulating the Toll-like receptor signaling pathway. In conclusion, ¥Äpep27 seems to alleviate TLR signaling and NLRP3 inflammasome activation to subsequently prevent AR.
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KEYWORD
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¥Äpep27, allergic rhinitis, toll-like receptor, NLRP3 inflammasome
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